WARNING: Can Some Tablets Increase the Risk of Blood Clots or Heart Problems?
Headlines claiming that certain tablets “cause blood clots, thrombosis, and heart attacks” need context. Some medications can increase the risk of these problems in certain people, but many medicines are safe and beneficial when prescribed appropriately.
Medicines that may be linked to increased clot or heart risks in some situations
1. Hormonal medicines
Examples include:
- Some estrogen-containing contraceptives
- Certain hormone replacement therapies
These may increase the risk of blood clots, especially in people with other risk factors such as smoking, older age, obesity, or a personal/family history of clotting disorders.
2. Some anti-inflammatory pain medicines (NSAIDs)
Examples include:
- Ibuprofen
- Naproxen
- Diclofenac
Long-term or high-dose use of some NSAIDs may increase the risk of heart attack or stroke in certain people, particularly those with existing cardiovascular disease.
3. Some cancer treatments
Certain chemotherapy drugs and targeted therapies can raise the risk of clotting because cancer itself can increase clot risk.
4. Some medicines affecting blood cells or hormones
Certain specialized treatments may alter clotting risk and require monitoring.
Warning signs of a possible blood clot or heart problem
Seek urgent medical care for:
- Sudden chest pain or pressure
- Shortness of breath
- Coughing blood
- Sudden swelling, pain, or warmth in one leg
- Sudden weakness on one side of the body
- Trouble speaking
- Severe unexplained headache
