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23 Strange Signs Your Kidneys Might Be in Trouble

The kidneys filter waste, balance fluids and minerals, help regulate blood pressure, and support red blood cell production. Early kidney disease often causes few or no symptoms, so many signs are nonspecific and can have other causes.

Here are 23 possible signs that your kidneys may not be functioning properly:

  1. Changes in urination (more or less frequent than usual)
  2. Waking up often at night to urinate
  3. Foamy or bubbly urine (can suggest protein in the urine)
  4. Blood in the urine
  5. Swelling of the feet, ankles, hands, or around the eyes
  6. Persistent fatigue or weakness
  7. Difficulty concentrating
  8. Loss of appetite
  9. Nausea or vomiting
  10. Metallic taste in the mouth
  11. Bad breath with an ammonia-like odor
  12. Dry, itchy skin
  13. Muscle cramps
  14. Shortness of breath
  15. High blood pressure that’s difficult to control
  16. Pain in the side or lower back (especially with kidney stones or infection)
  17. Pale skin due to anemia
  18. Feeling cold more often than usual
  19. Trouble sleeping
  20. Restless legs
  21. Frequent urinary tract infections
  22. Unexplained weight loss or swelling-related weight gain
  23. A general feeling of being unwell that doesn’t improve

Risk factors for kidney disease

You’re at higher risk if you have:

  • Diabetes
  • High blood pressure
  • Heart disease
  • A family history of kidney disease
  • Long-term frequent use of NSAID pain relievers (such as ibuprofen or naproxen)
  • Older age

When to seek medical care

Make an appointment with a healthcare professional if you have persistent symptoms such as swelling, changes in urination, or difficult-to-control blood pressure.

Seek urgent medical attention if you have:

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