Eight pills you shouldn’t take because they damage your kidneys

Claims like “eight pills you shouldn’t take because they damage your kidneys” are common online, but the reality is more nuanced: many medicines can affect kidney function in certain people or at certain doses, while others are safe when properly prescribed and monitored.

Some types of medicines that are known to have potential kidney risks include:

Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Examples: ibuprofen, naproxen, diclofenac
- Can reduce blood flow to the kidneys and may worsen kidney function, especially in older adults, people with kidney disease, dehydration, or heart problems.
Certain antibiotics
- Some antibiotics can stress or injure the kidneys, especially in people with existing kidney problems or when used at high doses.
Certain blood pressure medicines (in specific situations)
- Medicines such as ACE inhibitors or ARBs can change kidney blood tests. They are often kidney-protective in many patients, but require monitoring.
Diuretics (“water pills”)
- Can contribute to dehydration or electrolyte changes that affect kidney function if not properly managed.
Some chemotherapy medicines
- Certain cancer treatments can be toxic to the kidneys and require careful monitoring.
Lithium
- A medication used for some mental health conditions; long-term use can affect kidney function in some people.
Some antiviral or antifungal medicines
- Certain drugs in these groups may require kidney monitoring.
High-dose or unnecessary supplements and herbal products
- Some supplements can contain substances that may harm kidneys or interact with medicines.

Important: Do not stop prescribed medicines suddenly because of an online warning. The safest approach is to review your medicines with a doctor or pharmacist, especially if you have diabetes, high blood pressure, kidney disease, are older, or take multiple medications.

Signs that may need medical attention include: