5 Types of Medications That May Increase Heart Attack or Stroke Risk in Some Older Adults
Headlines claiming that a cardiologist has identified medicines that “cause” heart attacks or strokes can be misleading. Most medications are prescribed because their benefits outweigh their risks, but some medicines can increase cardiovascular risk in certain people—especially older adults with existing heart disease, high blood pressure, kidney problems, or multiple medications.
Never stop a prescribed medicine without speaking with your healthcare professional.
1. Certain Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Common pain relievers such as Ibuprofen and Naproxen can, in some people:
- Raise blood pressure
- Cause fluid retention
- Increase the risk of heart problems, especially with higher doses or long-term use
People with heart disease, kidney disease, or a history of stroke should discuss NSAID use with a healthcare professional.
2. Some Diabetes Medications (Depending on Individual Risk)
Diabetes medicines are important for reducing complications, but treatment choices depend on the person’s health profile.
Some older diabetes medications may require careful monitoring because of risks such as:
- Low blood sugar (which can stress the heart)
- Weight changes
- Fluid retention (with certain medicines)
Doctors choose medications based on a patient’s overall cardiovascular risk.
3. Certain Decongestants
Cold and flu medicines containing ingredients such as Pseudoephedrine can:
- Raise blood pressure
- Increase heart rate
- Potentially trigger problems in people with heart disease
Older adults with hypertension or heart rhythm problems should ask a pharmacist before using them.
4. Some Antipsychotic Medications
Certain antipsychotic medicines can be associated with increased cardiovascular risks, particularly in older adults with specific conditions.
Possible concerns include:
- Changes in blood pressure
- Metabolic effects (such as weight gain or blood sugar changes)
- Heart rhythm effects
These medicines should only be used when the benefits and risks have been carefully considered.
5. Some Hormone-Related Treatments
Certain hormone therapies may increase the risk of blood clots, which can contribute to stroke risk in some people.
Risk depends on factors such as:
- Age
- Smoking status
- Personal and family medical history
- Type and duration of therapy
Medicines That Protect the Heart
It is also important to remember that many commonly used medicines reduce heart attack and stroke risk, including:
- Blood pressure medicines
- Cholesterol-lowering medicines such as statins
- Certain diabetes medicines
- Blood thinners when appropriately prescribed
What Older Adults Should Do
✅ Keep an updated list of all medicines and supplements
✅ Ask a pharmacist to review possible interactions
✅ Check blood pressure regularly if advised
✅ Report new symptoms such as chest pain, unusual shortness of breath, fainting, or sudden weakness
✅ Do not stop heart or blood pressure medicines abruptly without medical guidance
